Application of ROC curve in the evaluation of laboratory tests for the diagnosis of hyperthyroidism

Objective To evaluate the accuracy of six laboratory tests for the diagnosis of hyperthyroidism. Methods The levels of TT3,TT4,FT3,FT4,rT3 and s-TSH in 150 patients with hyperthyroidism and 100 normal persons were measured by RIA and IRMA. Receiver operating characteristic (ROC) curve was drawn, and the area under the curve was calculated. Results The area under ROC curve of S s-TSH ,S FT3 ,S TT3 ,S FT4 ,S rT3 and S TT4 was 0.957,0.952,0.933,0.905,0.899 and 0.874 respectively. Conclusions The accuracy of s-TSH and FT3 is the best in diagnosis of hyperthyroidism according to the ROC curve evaluation.