Control Study between Quetiapine and Risperidone in the Treatment of Schizophrenia at Three Monnths

Objective To compare the therapeutic effects and side effects between quetiapine and risperidone in the treating of schizophrenia.Methods The positive and negative symptom scale(PANSS) and Calgary depression scale were used for schizophrenia(CDSS),the therapeutic effects and side effects were evaluated in 96 cases schizophrenic patients treated with quetiapine and 126 cases patients with risperidone,before therapy and the 2nd,4th,8th,12th weeks after treatment,respectively.Results The total response rates showed no significant difference between two groups.However,the recovery rates of quetiapine group showed modest higher than that of risperidone group(16.7% vs 8.7%,P=0.045).The negative and depressive factoral scores of PANSS,and the CDSS scores in quetiapine group were signifficant higher than those in risperidone group(P0.05).On the other hand,the prevalence of extra pyramidal system(EPS),such as akathisia,tremor and total EPS events in quetiapine group was significantly lower than in risperidone group.Conclusion The therapeutic effects and side effects through 3-month therapy of quetiapine showed different from those of risperidone.