多细胞生物
背景(考古学)
粘附
体外
细胞粘附分子
细胞生物学
抗药性
细胞粘附
细胞
生物
癌症研究
化学
生物化学
遗传学
古生物学
有机化学
作者
Simon F. Green,Arthur Frankel,Robert S. Kerbel
出处
期刊:Anti-cancer Drug Design
日期:1999-04-01
卷期号:14 (2): 153-68
被引量:32
摘要
Herein we review studies demonstrating resistance manifested at the multicellular level, a phenomenon referred to as intrinsic or acquired multicellular resistance (MR). In addition, due to the fact that such resistance can be recapitulated in vitro only when cells are adhered to one another in a three-dimensional culture context, we examine the roles of cell adhesion molecules and how they may contribute directly or indirectly to MR. Finally, we suggest an experimental approach to circumvent MR in the treatment of advanced, aggressive ascites tumors.
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