Effects of prostaglandins E2, I2 and D2 on pig nasal vasculature.

The effects of the prostaglandins (PG) E2, D2 and I2 were studied on the nasal vasculature of the anaesthetized pig. PGD2 caused vasoconstriction followed by a prolonged vasodilation whereas PGI2 only caused vasodilation. The effects of PGE2 were variable with vasoconstriction in 6 out of 7 pigs and vasodilation in 1 pig.