骨量减少
泼尼松龙
类骨质
胫骨
医学
内分泌学
内科学
骨质疏松症
外科
骨矿物
作者
Urszula Cegieła,Maria Pytlik,W Janiec
出处
期刊:PubMed
日期:2000-08-19
卷期号:52 (1): 33-7
被引量:4
摘要
The excess of glucocorticosteroids leads to the development of osteopenia. A decreased bone formation rate and an increased bone resorption rate are observed. The aim of the present study was to investigate the effects of alpha-escin on the experimental prednisolone-induced osteopenia. The experiments were carried out on male Wistar rats with initial body weight of 240-310 g, divided into 4 groups (n = 6): Control, Alpha-escin, Prednisolone, Prednisolone + alpha-escin. Prednisolone (5 mg/kg im daily) and/or alpha-escin (100 mg/kg po daily) were administered for 28 days. Transverse cross-section surfaces of the cortical diaphysis and of the marrow cavity in the tibia, transverse growth, width of endosteal and periosteal osteoid, thickness of trabeculae and width of epiphyseal cartilage were examined. Prednisolone administration caused osteopenic changes in rat bones. Alpha-escin administered to the control rats did not exert statistically significant influence on the investigated bone parameters. Alpha-escin administration to prednisolone-treated rats slightly reduced the unfavorable effects of prednisolone on width of periosteal and endosteal osteoid and periosteal transverse growth in the tibia.
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