Local blood microcirculation on the surface of skin not only reflect part but also systemic changes of pathophysiology .Information of microcirculation play an very important role in realizing organic function,discovering and diagnosing various diseases.Multifarious methods of detecting microcirculation provide us a number of information in microcirculation.Especially the development of modern molecule imaging technology,it turned observation of microcirculation into vivid,real time,noninvasive examination,and arrived at cell or molecule level.