Nanometer technology is a technical revolution in the 21 century, nanomaterials as important ingredient of nanometer technology, have permeated many subjects, and are applied generally in the medical domain. Because of nanomaterials characteristic scilicet small size effect, surface effect, quantum size effect and macroscopic quantum tunnel effect, they improve the selectivity, the accurate, the reproducibility, the sensitivity and response speed of the sensor, when nanomaterials are applied in electrochemical immunosensor, piezo-immunosensor and optical immunosensor, and make sensor devel-op for miniaturization and integrating.