Objective To study the surgery of temporal lobe epilepsy caused by mass lesions or hippocampus sclerosis. Methods Fourty patients of intractable epilepsy, of which 19 had intraaxial temporal neoplasm and 21 had hippocampus sclerosis diagnosed by MRI or CT, accepted surgical excision. The removed part in the patients with temporal neoplasm included mass lession, hippocampus, and amygdala. The removed part in the patients with hippocampus Sclerosis included hippocampus and amygdala. The histologic changes were observed in the excised samples. Results Thirty - five of 40 cases were followed up. The epilepsy was relieved completely in 30 cases. The other 5 cases were still dependent on drugs, but the epilepsy was relieved obviously. Conclusion Hippocampus sclerosis is the predominant factor of temporal lobe epilepsy, and the effect of surgical excision is satisfactory.