单核苷酸多态性
人口
医学
遗传关联
基因型
人口学
人体测量学
超重
优势比
全基因组关联研究
作者
Jai Prakash,Neena Srivastava,Shally Awasthi,C. G. Agarwal,S. M. Natu,Naresh Rajpal,Balraj Mittal
标识
DOI:10.3109/03014460.2011.614278
摘要
Background: Obesity is a very common disorder directly linked with various diseases such as type-2 diabetes, hypertension and atherosclerosis. Variants in the FTO gene have been associated with Body Mass Index in Western European and North American populations.Aim: This study analysed the association between the FTO gene variant rs17817449 (G>T) and obesity and obesity-related phenotypes in a north Indian population.Subjects and methods: A total of 642 subjects, 309 obese and 333 non-obese individuals, were included in this case-control study. Genotyping of FTO gene (rs17817449) polymorphism for all subjects was performed by the PCR-RFLP method.Results: Significant associations were found for FTO rs17817449 SNP with obesity and obesity-related phenotypes. The strongest associations were observed between the rs17817449 and fasting blood glucose, insulin, homeostasis model of assessment—insulin resistance (HOMA-IR) and fat mass under a recessive model.Conclusions: This study replicated the genetic associati...
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