Engineering Smart Bimetallic Ionic-Site MOF Nanozyme Nanocomposites for Microenvironment-Responsive Dynamic Therapy of Periapical Periodontitis

, using a rat AP model, the nanocomposite suppressed alveolar bone resorption by blocking the NF-κB/HIF-1α/NLRP3 signaling axis to inhibit pyroptosis. Concurrently, it induced macrophage polarization toward the anti-inflammatory M2 phenotype, thereby reprogramming the microenvironment for bone regeneration. This microenvironment-responsive nanoplatform offers a promising strategy for precision therapy of AP by integrating infection control, immune regulation, and tissue regeneration.