小RNA
乳腺癌
下调和上调
转移
肿瘤科
医学
阶段(地层学)
实时聚合酶链反应
癌症
内科学
癌症研究
逆转录酶
逆转录聚合酶链式反应
聚合酶链反应
基因表达
基因
生物
生物化学
古生物学
作者
AmirReza Hesari,Mitra Azizian,Hassan Darabi,Abolfazl Nesaei,Seyede Atefe Hosseini,Reza Salarinia,Amir Ali Motaghi,Faezeh Ghasemi
摘要
One of the most lethal cancers among women is breast cancer. MicroRNAs (miRNAs) can be of great importance in the early detection of breast cancer. This study aimed to investigate some miRNAs in the serum of patients with breast cancer compared with the control group. Total RNA was extracted from the serum of patients with breast cancer and healthy volunteers. The expression levels of miRNAs and the genes were assessed using real-time reverse transcriptase-polymerase chain reaction with specific primers. Our data showed that miR-25 and miR-133 were downregulated, and miR-17 was upregulated in patients with breast cancer. Upregulation of miR-17 is related to the poor survival time and increased cell proliferation. The reduced expression of miR-133 and miR-25 is significantly associated with clinical stage, metastasis, and survival time of patients with breast cancer. Expressions of miRNAs miR-17, miR-25, and miR-133 are altered in patients with clinical stage, metastasis, poor survival time.
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