斑马鱼
甲状腺
后代
内科学
内分泌学
三碘甲状腺素
激素
生物
毒性
下丘脑-垂体-甲状腺轴
男科
怀孕
医学
基因
生物化学
遗传学
作者
Guiyang Shi,Jinxing Wang,Hua Guo,Nan Sheng,Qianqian Cui,Yitao Pan,Yong Guo,Yan Sun,Jiayin Dai
标识
DOI:10.1016/j.scitotenv.2019.02.198
摘要
Although 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), an alternative to perfluorooctanesulfonate (PFOS), has been regularly detected in different environmental matrices, information regarding its toxicity remains limited. To explore the transgenerational thyroid-disrupting capacity of F-53B, adult zebrafish (F0) were exposed to different concentrations of F-53B (0, 5, 50, or 500μg/L) for 180d, with their offspring (F1 and F2) subsequently reared in uncontaminated water. Thyroid disturbances were then examined in the three (F0, F1, and F2) generations. For F0 adult fish, thyroxine (T4) increased in both sexes after exposure to 50μg/LF-53B, whereas 3,5,3'-triiodothyronine (T3) decreased in all groups, except for 50μg/LF-53B-treated males. For F1 embryos, parental exposure resulted in F-53B transfer as well as an increase in T4 content. At 5days post-fertilization, the significant increase in T4 and decrease in T3 were accompanied by a decrease in body length, increase in mortality, and increase in uninflated posterior swim bladder occurrence in F1 larvae. Although thyroid hormone levels were not changed significantly in F1 adult fish or F2 offspring compared with the control, the transcription levels of several genes along the hypothalamus-pituitary-thyroid axis were significantly modified. Our study demonstrated that F-53B possesses transgenerational thyroid-disrupting capability in zebrafish, indicating it might not be a safer alternative to PFOS.
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