医学
肾功能
内科学
肥厚性心肌病
危险系数
肾脏疾病
置信区间
人口
心脏病学
比例危险模型
队列
共病
心肌病
胃肠病学
心力衰竭
环境卫生
作者
Fang‐Yang Huang,Jialiang Zhang,Bao‐Tao Huang,Yong Peng,Shijian Chen,Mao Chen
标识
DOI:10.1016/j.cca.2020.11.022
摘要
The relationship between renal function and outcomes among patients with hypertrophic cardiomyopathy (HCM) remains undefined. We sought to investigate the prevalence of renal dysfunction and its prognostic value in HCM patients. A total of 581 patients with HCM were consecutively recruited. The chronic kidney disease epidemiology equation was used to estimate the glomerular filtration rate (eGFR). Patients were divided into 2 eGFR categories: ≥60 or <60 ml/min/1.73 m2. The predictive value of renal function was assessed using Cox regression. The proportions of eGFR 60–90 ml/min/1.73 m2 and <60 ml/min/1.73 m2 were 41.8% and 15.3%, respectively. Estimated GFR independently predicted the risk of all-cause mortality [HR 0.98, 95% confidence interval (CI) 0.96–0.99, P < 0.001]. Compared to those with eGFR ≥ 60 ml/min/1.73 m2, patients with eGFR < 60 ml/min/1.73 m2 were independently associated with all-cause mortality (HR, 3.42 95% CI 1.86–6.28), cardiovascular mortality (HR 2.98, 95% CI 1.36–6.50) and combined adverse outcomes (HR 1.60, 95% CI 1.02–2.49). HRs for all-cause mortality with renal dysfunction were attenuated in patients with older ages (P for interaction = 0.034). Renal dysfunction is a common comorbidity in HCM. Renal function is an independent predictor of outcomes in patients with HCM. These findings highlight the clinical importance of renal dysfunction in HCM.
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