光热治疗
材料科学
手性(物理)
纳米颗粒
纳米技术
光热效应
圆极化
可见光谱
超分子手性
纳米材料
光化学
光电子学
分子
光学
超分子化学
化学
有机化学
微带线
夸克
物理
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
作者
Yiwen Li,Ziwei Miao,Zhengwen Shang,Ying Cai,Jiaji Cheng,Xiaoqian Xu
标识
DOI:10.1002/adfm.201906311
摘要
Abstract Chirality‐based semiconducting nanocrystals, as an emerging area, are envisioned to have great potential in chiral sensing, biomedicine, and chiroptical devices. Herein, chiral substoichiometric molybdenum oxide ( l / d ‐Cys‐MoO 3− x ) nanoparticles are synthesized via step‐by‐step reduction treatment with chiral cysteine molecules. The obtained nanoparticles are used as visible‐ and near‐infrared‐light dual responsive photothermal therapy agent for tumor cell ablation. Notably, the chiral nanoparticles show chiral selectivity for incident light, i.e., when irradiated by left‐circularly polarized light, l ‐Cys‐MoO 3− x is the most sensitive agent giving the highest mortality for HeLa cell ablation in vitro, and vice versa for right‐circularly polarized light with d ‐Cys‐MoO 3− x . In comparison to traditional photothermal therapy with near‐field light source, the investigations with chiral visible light at 532 nm indicate the possibility of chiral Cys‐MoO 3− x nanoparticles for visible light‐based phototherapy via metal–ligand charge transfer chirality, which provides insights for new methods in nanotechnology supported photothermal treatments.
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