细胞生长
癌症
细胞周期
癌基因
癌症研究
转移
下调和上调
生物
细胞
细胞生物学
生物化学
遗传学
基因
作者
Haixai Li,Junyan Zhang,Cheng Zhen,Bob Yang,Limin Feng
出处
期刊:PubMed
日期:2018-01-01
卷期号:10 (7): 1949-1960
被引量:7
摘要
Gankyrin (also known as PSMD10 or p28GANK), engages in diverse biological processes, including cellular growth, proliferation and invasion. Several studies have demonstrated that Gankyrin is a candidate oncogene. In parallel, the dysregulation of Gankyrin has been observered in a variety of human cancer. Overexpression of Gankyrin is involved in tumor initiation and progression by regulating several signaling pathways that control cell-cycle process, cell growth, apoptosis, et al. On the contrary, downregulation of Gankyrin significantly inhibits cell growth, proliferation and metastasis. Therefore, Gankyrin appears to be a potential target for tumor therapy. Herein, this review summarizes the current knowledge in understanding the biological functions and oncogenic role of Gankyrin in human cancers from the perspective of clinical-pathological significances, aiming to provide guidance for the development of Gankyrin-targeted therapy.
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