Estrogen effects on orthodontic tooth movement and orthodontically-induced root resorption

Estrogen is an essential regulator of the bone tissue. The remodeling of the alveolar bone and periodontal ligament is the basis of orthodontic tooth movement (OTM). There is a negative coregulation between physiological estrogen levels and the rate of OTM. As a possible inhibitory factor of OTM, estrogen suppresses bone resorption by inhibiting osteoclastic differentiation and restraining osteoclast lifespan though multiple pathways and cytokines, leading to the suppression of the initiation step of bone remodeling. On the other hand, estrogen stimulates osteoblastic differentiation and function. Estrogen receptor-α (ERα) involves in the osteogenic responses to mechanical stimulation, and the ERα expression is regulated positively by the levels of circulatory estrogen. Orthodontically induced root resorption (OIRR) is a common side-effect of orthodontic treatment. Estrogen may have some inhibitory effects on OIRR, but more studies are needed to get an effective conclusion.