佐剂
明矾
CTL公司*
免疫系统
抗原
癌症疫苗
细胞毒性T细胞
葡聚糖
抗体
免疫增强剂
效价
免疫学
免疫
癌症免疫疗法
抗体效价
免疫疗法
化学
CD8型
生物
生物化学
体外
有机化学
作者
Yonghui Liu,Mingjing Li,Haomiao Zhu,Zhe Jing,Xiaona Yin,Kun Wang,Zhangyong Hong,Wei Zhao
标识
DOI:10.1016/j.cclet.2021.01.035
摘要
We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated inside β-glucan particles (GP-Al). The constructed vaccine induced strong MUC1 antigen specific IgG antibody titers and enhanced CD8+ T cells cytotoxic effect to kill tumor cells. These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines.
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