光热治疗
二硫化钼
纳米载体
阿霉素
适体
药物输送
生物相容性
化学
聚乙二醇
PEG比率
纳米技术
癌细胞
生物物理学
光热效应
材料科学
癌症
化疗
生物化学
医学
分子生物学
经济
内科学
财务
外科
冶金
生物
作者
Shundong Cai,Jun Yan,Hongjie Xiong,Qing Wu,Hang Xing,Yanfei Liu,Song Liu,Zhenbao Liu
标识
DOI:10.1016/j.ijpharm.2020.119948
摘要
Molybdenum disulfide (MoS2), one representative 2D nanomaterial, has recently emerged as a unique platform in the biomedical field. However, its application in drug delivery systems should be further exploited. Here, we report a novel tumor cell targeting and lysosomal acidic environment/NIR laser dual responsive drug delivery system for synergetic chemo-photothermal treatment of cancer cells. The MoS2 nanosheets were loaded with chemotherapy drug doxorubicin (DOX) and coated with polydopamine (PDA) layer. Then, thiolated aptamer AS1411 and polyethylene glycol (PEG) were modified onto MoS2 nanosheets through Michael addition reaction to construct [email protected]2 nanosheets. The aptamer modification endowed the nanoplatform with targeting ability to breast cancer MCF-7 cells. MoS2 and PDA converted 808 nm NIR laser into heat and played the role of photothermal therapy (PTT). Tumor lysosomal acidic environment and NIR laser irradiation accelerated the release of DOX from the nanosheets. The nanocarrier Apt-PEG-PDA-MoS2 showed good biocompatibility, and [email protected]2 showed synergetic chemo-photothermal therapy effects with significantly enhanced anti-tumor efficacy, suggesting that this MoS2-based drug delivery platform is promising for targeted and synergetic treatment of cancer.
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