化学发光
量子产额
能量转移
纳米颗粒
产量(工程)
癌症
费斯特共振能量转移
材料科学
癌症检测
量子
纳米技术
共振(粒子物理)
荧光
化学
物理
原子物理学
医学
化学物理
光学
色谱法
量子力学
复合材料
内科学
作者
Jueun Jeon,Dong Gil You,Wooram Um,Jeongjin Lee,Chan Ho Kim,Sol Shin,Seunglee Kwon,Jae Hyung Park
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-05-22
卷期号:6 (21)
被引量:53
标识
DOI:10.1126/sciadv.aaz8400
摘要
Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)-mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational applications. Here, we report CRET-based nanoparticles (CRET-NPs) to achieve quantum yield-enhanced cancer phototheranostics by reinterpreting the hidden nature of CRET. Owing to reactive oxygen species (ROS)-responsive CO2 generation, CRET-NPs were capable of generating a strong and long-lasting photoacoustic signal in the tumor tissue via thermal expansion-induced vaporization. In addition, the CRET phenomenon of the NPs enhanced ROS quantum yield of photosensitizer through both electron transfer for an oxygen-independent type I photochemical reaction and self-illumination for an oxygen-dependent type II photochemical reaction. Consequently, owing to their high ROS quantum yield, CRET-NPs effectively inhibited tumor growth with complete tumor growth inhibition in 60% of cases, even with a single treatment.
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