表观遗传学
疾病
癌症研究
医学
血管生成
生物信息学
生物
内科学
肿瘤科
基因
遗传学
DNA甲基化
基因表达
作者
Colm J. O’Rourke,Patricia Munoz‐Garrido,Jesper B. Andersen
出处
期刊:Hepatology
[Wiley]
日期:2020-12-03
卷期号:73 (S1): 62-74
被引量:25
摘要
Cholangiocarcinoma (CCA) encompasses a heterogeneous collection of malignancies for which diagnostic biomarkers are lacking and population screening is infeasible because of its status as a rare disease. Coupled with high postsurgical recurrence rates among the minority of patients diagnosed at resectable stages, systemic clinical management will inevitably be required for the majority of patients with CCA with recurrent and advanced disease. In this review, we discuss the therapeutic potential of different classes of molecular targets at various stages of development in CCA, including those targeted to the tumor epithelia (oncogenic, developmental, metabolic, epigenomic) and tumor microenvironment (angiogenesis, checkpoint regulation). Furthermore, we discuss the successes and failures of CCA-targeted therapies, emphasizing key lessons learned that should pave the way for future molecular target evaluation in this uncommon yet bona fide target-rich disease.
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