脂类学
生物
脂质代谢
全基因组关联研究
计算生物学
基因组
基因座(遗传学)
数量性状位点
遗传学
进化生物学
基因
生物化学
基因型
单核苷酸多态性
作者
Vanessa Linke,Katherine A. Overmyer,Ian Miller,Dain R. Brademan,Paul D. Hutchins,Edna A. Trujillo,Thiru R. Reddy,John N. Russell,Emily M. Cushing,Kathryn L. Schueler,Donald S. Stapleton,Mary E. Rabaglia,Mark P. Keller,Daniel M. Gatti,Gregory R. Keele,Duy T. Pham,Karl W. Broman,Gary A. Churchill,Alan D. Attie,Joshua J. Coon
标识
DOI:10.1038/s42255-020-00278-3
摘要
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively annotating lipid species and their genetic basis. Mass spectrometry-based discovery lipidomics offers the potential to globally survey lipids and their relative abundances in various biological samples. To discover the genetics of lipid features obtained through high-resolution liquid chromatography-tandem mass spectrometry, we analysed liver and plasma from 384 diversity outbred mice, and quantified 3,283 molecular features. These features were mapped to 5,622 lipid quantitative trait loci and compiled into a public web resource termed LipidGenie. The data are cross-referenced to the human genome and offer a bridge between genetic associations in humans and mice. Harnessing this resource, we used genome-lipid association data as an additional aid to identify a number of lipids, for example gangliosides through their association with B4galnt1, and found evidence for a group of sex-specific phosphatidylcholines through their shared locus. Finally, LipidGenie's ability to query either mass or gene-centric terms suggests acyl-chain-specific functions for proteins of the ABHD family.
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