Parkin-mediated mitophagy in beige adipose tissue

Recently, Ramakrishnan and colleagues studied the degradation of caloric restriction-induced beige adiposes [ [1] Mooli R.G.R. Mukhi D. Watt M. et al. Sustained mitochondrial biogenesis is essential to maintain caloric restriction-induced beige adipocytes. Metabolism. 2020; 107: 154225https://doi.org/10.1016/j.metabol.2020.154225 Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar ]. CR-induced adipose beiging is rapidly transit into white adipocytes when CR withdrawn. However, during beige-to-white transition of their CR-model, there was no significant difference between wild type and Park2 KO mouse.