神经退行性变
细胞生物学
趋化因子
CX3CR1型
生物
路易体
趋化因子受体
医学
T细胞
受体
疾病
神经科学
免疫系统
病理
帕金森病
共核细胞病
化学
痴呆
α-突触核蛋白
免疫学
遗传学
作者
David Gate,Emma Tapp,Olivia Leventhal,Marian Shahid,Tim J. Nonninger,Andrew C. Yang,Katharina Strempfl,Michael S. Unger,Tobias Fehlmann,Hamilton Oh,Divya Channappa,Victor W. Henderson,Andreas Keller,Ludwig Aigner,Douglas Galasko,Mark M. Davis,Kathleen L. Poston,Tony Wyss‐Coray
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-10-15
卷期号:374 (6569): 868-874
被引量:205
标识
DOI:10.1126/science.abf7266
摘要
Autoimmunity in Lewy body dementia Lewy body dementia (LBD) is a brain disease that leads to progressive decline in thinking, movement, and independent function. It results from the build-up of microscopic deposits called Lewy bodies, which develop from the aggregation of a misfolded protein called α-synuclein. Gate et al . observed immune cells known as T cells in the brains of LBD patients (see the Perspective by Krot and Rolls). Genomics analysis revealed that T cells traffic to the LBD brain and are associated with neuronal damage. When stimulated with α-synuclein, LBD patient T cells secrete an inflammatory protein known to damage neurons. These findings suggest an unexpected detrimental role of the immune system in LBD. —SMH
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