Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress

Luteolin normalizes the estrus cycle, ovarian morphological changes, improves serum sexual hormone levels, reduces insulin resistance, prompts PI3K/Akt signaling, improves antioxidative response, and upregulates Nrf2 signaling in PCOS rats. Luteolin has a potential to serve as a therapeutic agent in preventing and treating PCOS.