生物利用度
两亲性
化学
姜黄素
保健品
纳米颗粒
壳聚糖
疏水效应
溶解度
纳米技术
有机化学
材料科学
聚合物
生物化学
共聚物
生物信息学
生物
作者
Meng Yang,Jingbo Liu,Yajuan Li,Qi Yang,Chunmei Liu,Xuanting Liu,Biying Zhang,Hui Zhang,Ting Zhang,Zhiyang Du
标识
DOI:10.1021/acs.jafc.1c08186
摘要
The comprehensive utilization of food-derived nutraceuticals with different polarities has been extremely restricted by their poor bioavailability and coexistence in a single system. This study aimed to fabricate a self-assembly of amphiphilic nanoparticles (NPs) for the hydrophilic EWDP and hydrophobic curcumin based on the carboxymethyl chitosan (CMCS) shell and γ-cyclodextrin (γ-CD) core. Notably, EWDP could cooperate with CMCS to yield superior colloidal properties with an excellent curcumin aqueous solubility and co-encapsulation capacity (>10%) for the NPs (pH 2.0-7.0). This phenomenon was mainly ascribed to the additional hydrogen-bonding network and hydrophobic interaction introduced by EWDP. Besides, the overall antioxidant activity, bioaccessibility, gastrointestinal stability, and Caco-2 cell absorption properties were significantly improved in the presence of EWDP (>20% increase). Therefore, EWDP could function as both a potential affinity agent and a nutrition enhancer to expand the co-delivery applications for diverse nutraceuticals with promising oral bioavailability enhancement in food and pharmaceutical areas.
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