免疫系统
转录组
结直肠癌
免疫疗法
癌症研究
腺癌
生物
肿瘤微环境
医学
癌症
基因
免疫学
基因表达
遗传学
作者
Rongxin Zhang,Yu Feng,Wenjuan Ma,Yanying Guo,Min Luo,Young Li,Yupeng Zang,Dong Xuan,Shi-Xun Lu,Qiang Guo,Qumiao Xu,Huanyi Chen,Yijian Li,Longqi Liu,Ao Chen,Gong Chen,Xun Xu
标识
DOI:10.1016/j.fmre.2022.01.036
摘要
The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients. Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution, hi-res spatial investigations are limited. In this study, we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal specimens to identify the molecular pattern involved in a discontinuous inflammatory response in pathologically annotated cancer regions. Based on the location of spatially varied gene expression, we unmasked the spatially-varied immune ecosystem and identified the locoregional “warmed-up” immune response in predefined “cold” tumor with substantial infiltration of immune components. This “warmed-up” immune profile was found to be associated with the in-situ copy number variance and the tissue remodeling process. Further, “warmed-up” signature genes indicated improved overall survival in CRC patients obtained from TCGA database.
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