生物传感器
2019-20冠状病毒爆发
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
材料科学
Sars病毒
2019年冠状病毒病(COVID-19)
病毒学
纳米技术
医学
传染病(医学专业)
内科学
疾病
爆发
作者
Yusi Peng,Chenglong Lin,Yanyan Li,Yong Gao,Jing Wang,Jun He,Zhengren Huang,Jianjun Li,Xiaoying Luo,Yong Yang
出处
期刊:Matter
[Elsevier]
日期:2022-02-01
卷期号:5 (2): 694-709
被引量:65
标识
DOI:10.1016/j.matt.2021.11.028
摘要
The current COVID-19 pandemic urges us to develop ultra-sensitive surface-enhanced Raman scattering (SERS) substrates to identify the infectiousness of SARS-CoV-2 virions in actual environments. Here, a micrometer-sized spherical SnS2 structure with the hierarchical nanostructure of "nano-canyon” morphology was developed as semiconductor-based SERS substrate, and it exhibited an extremely low limit of detection of 10−13 M for methylene blue, which is one of the highest sensitivities among the reported pure semiconductor-based SERS substrates. Such ultra-high SERS sensitivity originated from the synergistic enhancements of the molecular enrichment caused by capillary effect and the charge transfer chemical enhancement boosted by the lattice strain and sulfur vacancies. The novel two-step SERS diagnostic route based on the ultra-sensitive SnS2 substrate was presented to diagnose the infectiousness of SARS-CoV-2 through the identification standard of SERS signals for SARS-CoV-2 S protein and RNA, which could accurately identify non-infectious lysed SARS-CoV-2 virions in actual environments, whereas the current PCR methods cannot.
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