ADC Linkers Strategies for the Release of Alcohol-containing Payloads

In spite of tremendous advances in the design of ADC linkers, there continue to be limited options for the release of payloads that do not contain a free amino group. Herein, we review a variety of cleavable linker strategies that have been employed for both phenolic and aliphatic alcohols. We highlight the advantages and shortcomings of each approach, particularly focusing on technology that has advanced into the clinic and those approaches that are broadly applicable to structurally diverse alcohol-containing payloads.