Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes

嗅觉系统 嗅觉 嗅觉记忆 认知 糖尿病 神经科学 气味 认知功能衰退 神经心理学 心理学 2型糖尿病 医学 内科学 中枢神经系统 痴呆 内分泌学 嗅球 疾病
作者
Zhou Zhang,Bing Zhang,Xin Wang,Xin Zhang,Qing X. Yang,Qing Zhao,Jiaming Lu,Yan Bi,Dalong Zhu
出处
期刊:Diabetes [American Diabetes Association]
卷期号:67 (5): 994-1006 被引量:50
标识
DOI:10.2337/db17-1274
摘要

Type 2 diabetes is reported to be associated with olfactory dysfunction and cognitive decline. However, whether and how olfactory neural circuit abnormalities involve cognitive impairment in diabetes remains uncovered. This study thus aimed to investigate olfactory network alterations and the associations of odor-induced brain activity with cognitive and metabolic parameters in type 2 diabetes. Participants with normal cognition, including 51 patients with type 2 diabetes and 41 control subjects without diabetes, underwent detailed cognitive assessment, olfactory behavior tests, and odor-induced functional MRI measurements. Olfactory brain regions showing significantly different activation between the two groups were selected for functional connectivity analysis. Compared with the control subjects, patients with diabetes demonstrated significantly lower olfactory threshold score, decreased brain activation, and disrupted functional connectivity in the olfactory network. Positive associations of the disrupted functional connectivity with decreased neuropsychology test scores and reduced pancreatic function were observed in patients with diabetes. Notably, the association between pancreatic function and executive function was mediated by olfactory behavior and olfactory functional connectivity. Our results suggested the alteration of olfactory network is present before clinically measurable cognitive decrements in type 2 diabetes, bridging the gap between the central olfactory system and cognitive decline in diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
一一完成签到 ,获得积分10
刚刚
nnn发布了新的文献求助10
1秒前
nnn发布了新的文献求助10
1秒前
CCC完成签到 ,获得积分10
1秒前
nnn发布了新的文献求助10
1秒前
nnn发布了新的文献求助10
1秒前
基尔霍夫完成签到,获得积分10
1秒前
墨懿完成签到,获得积分10
1秒前
这个人不带手机完成签到 ,获得积分10
1秒前
雪碧发布了新的文献求助10
2秒前
可靠松鼠发布了新的文献求助10
2秒前
ranlan发布了新的文献求助10
2秒前
斗牛的番茄完成签到 ,获得积分10
2秒前
王金豪完成签到,获得积分10
2秒前
2秒前
达进完成签到,获得积分10
3秒前
3秒前
融融虫完成签到,获得积分10
3秒前
FXL发布了新的文献求助10
3秒前
睡个好觉完成签到,获得积分10
3秒前
tangtang完成签到 ,获得积分10
3秒前
NexusExplorer应助Nicole采纳,获得10
3秒前
苹果匪发布了新的文献求助10
4秒前
高ggg完成签到,获得积分10
4秒前
丰富无色完成签到,获得积分10
4秒前
4秒前
4秒前
Kn1ght发布了新的文献求助10
4秒前
4秒前
soso完成签到,获得积分10
5秒前
5秒前
斯文的白玉应助Cecilia采纳,获得10
5秒前
Ace发布了新的文献求助10
5秒前
求助吃草小河马完成签到,获得积分10
5秒前
6秒前
IMF完成签到,获得积分10
6秒前
无极微光应助huan采纳,获得20
6秒前
杨123完成签到,获得积分10
6秒前
6秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Organizational Behavior 510
Management and the Arts 510
Matrix Methods in Data Mining and Pattern Recognition Second Edition 510
Rosenblum, Global Change Biology 500
CLSI VET01S-2024 Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals (7th Ed) 500
DIPPR Project 801 - Full Version 380
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 计算机科学 化学工程 工程类 有机化学 物理 复合材料 生物化学 内科学 细胞生物学 基因 遗传学 免疫学 冶金 光电子学 癌症研究
热门帖子
关注 科研通微信公众号,转发送积分 7766694
求助须知:如何正确求助?哪些是违规求助? 9310506
关于积分的说明 20317698
捐赠科研通 7351713
什么是DOI,文献DOI怎么找? 3315152
关于科研通互助平台的介绍 2464624
邀请新用户注册赠送积分活动 2329811