Synthesis of thienyl-substituted isochromene derivatives through gold-catalyzed tandem heteroarylation/cycloisomerization of ortho-alkynylbenzaldehydes with thiophenes

We describe herein a gold-catalyzed tandem heteroarylation/cycloisomerization reaction of ortho-alkynylbenzaldehydes with thiophenes. By this reaction, a variety of 1-(thiophen-2-yl)-1H-isochromene derivatives can be obtained in good yield.