生物
吞噬作用
免疫系统
功能(生物学)
膜皱折
类风湿性关节炎
免疫学
细胞内
巨噬细胞
炎症
细胞生物学
细胞
微生物学
生物化学
细胞骨架
体外
作者
Diego De León-Oliva,Cielo García‐Montero,Oscar Fraile‐Martínez,Diego Liviu Boaru,Luis David García-Puente,Antonio Rios-Parra,Maria J. Garrido-Gil,Carlos Casanova-Martín,Natalio García‐Honduvilla,Julia Buján,Luis G. Guijarro,Melchor Álvarez‐Mon,Miguel Á. Ortega
出处
期刊:Biology
[Multidisciplinary Digital Publishing Institute]
日期:2023-05-09
卷期号:12 (5): 694-694
被引量:16
标识
DOI:10.3390/biology12050694
摘要
Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.
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