Fluorescence Ratiometric Antibiotic Detection with a Single Lanthanide Metal‐Organic Framework

Abstract Antibiotic residues are currently an increasing threat for human health and the ecosystem, and specific and rapid real‐time sensing of antibiotics is a big challenge. To realize specific sensing by rapid fluorescent sensors, a lanthanide metal‐organic framework (MOF) containing dual emissive centers has been developed with high sensing selectivity and sensitivity. Owing to the self‐calibration ability, the dual‐center Tb‐MOF exhibits higher selectivity towards furazolidone (FZD) and nitrofural (NZF) among the reported MOF sensors. Additionally, the corresponding ratiometric detection mode also realized specific sensing of other tested antibiotics. Besides, the single‐Tb 3+ ‐based dual‐emission MOF in this work is expected to support the development of fluorescent sensors with high sensitivity and selectivity for environmental safety purposes.