AbstractInsecticide resistance in agricultural pests poses a critical challenge to global food production, driving the need for innovative solutions. Genomic studies have revolutionized our understanding of the mechanisms underlying resistance, providing detailed insights into genetic mutations, detoxification pathways, and adaptive changes that allow pests to survive chemical control measures. This study explores the evolutionary dynamics of insecticide resistance by reviewing genomic tools, key case studies, and the molecular basis of resistance in several major agricultural pests.