Advances on the role of mycobiome in atopic dermatitis

Atopic dermatitis (AD) is a prevalent chronic skin disorder with a complex etiology involving genetic, environmental, and immunological factors. The skin mycobiome has been increasingly implicated in the pathophysiology of AD. Provides a comprehensive overview of current understanding regarding the function of the skin mycobiome in AD, along with emerging research opportunities within this domain. In AD, the predominant fungi are Malassezia species, primarily M. restricta and M. globosa , yet their abundance is reduced, while the abundance of non- Malassezia fungi increases, leading to enhanced fungal diversity. Mycobiome may play a role in AD by eliciting immune responses or through interactions with other microorganisms. This review highlights the growing importance of mycobiome in AD, particularly Malassezia offers insights into disease pathogenesis and progression.