Cascade‐Catalytic MXene‐AuPt Nanozyme for Photothermal‐Chemodynamic Therapy and Dual‐Mode Imaging of Breast Cancer

Comprehensive Summary The efficacy of chemodynamic therapy (CDT) is limited by low endogenous H 2 O 2 levels, and monotherapy often fails to achieve complete tumor eradication. To overcome these challenges, we constructed a multifunctional nanoplatform named Ti 3 C 2 T x @AuPt‐FA (MAPF). The key innovation of this work lies in a self‐supplementing cascade catalytic cycle. Au/Pt nanozymes provided H 2 O 2 to generate ·OH by continuously consuming glucose, thus enhancing CDT. Photothermal therapy could synergistically enhance the effect of CDT. The MAPF platform exhibited high catalytic activity and efficient photothermal conversion ( η = 52.8%). It potently induced apoptosis in 4T1 cells in vitro and achieved efficient tumor ablation in vivo . Moreover, MAPF enabled prolonged tumor retention and permitted real‐time monitoring via computed tomography (CT) and infrared thermal (IRT) imaging. Safety evaluations confirmed that the platform possessed excellent biocompatibility with no significant systemic toxicity. This work provides a typical self‐sustaining nanoplatform that addresses the fundamental limitations of CDT, offering a powerful theranostic strategy with high translational potential for precise breast cancer treatment.