脑脊液
慢波睡眠
多导睡眠图
人脑
睡眠(系统调用)
动力学(音乐)
清醒
神经科学
睡眠神经科学
睡眠阶段
眼球运动
快速眼动睡眠
睡眠纺锤
脑电图
非快速眼动睡眠
睡眠开始
医学
K-络合物
唤醒
大脑活动与冥想
淋巴系统
三角波
心理学
信号(编程语言)
脑电波
作者
Makoto Uji,Xuemei Li,An Saotome,Ryosuke Katsumata,R. Allen Waggoner,Chisato Suzuki,Kenichi Ueno,Sayaka Aritake‐Okada,Masako Tamaki
标识
DOI:10.1073/pnas.2509626122
摘要
How sleep maintains our healthy brain function has remained one of the biggest mysteries in neuroscience, medical settings, and daily lives. While cerebrospinal fluid (CSF) during sleep has been implicated in metabolic waste reduction in animals, how CSF dynamics are driven in the healthy human brain during deep sleep remains elusive. A myriad of research has shown that crucial cognitive processing manifests in slow-wave and rapid-eye movement (REM) sleep, suggesting that a key to maintaining brain functions lies in deep sleep. By leveraging a simultaneous sparse-functional MRI and polysomnography method, we demonstrate that deep sleep-specific CSF dynamics are associated with spontaneous brain oscillations in healthy young human participants. Slow waves and sleep spindles during slow-wave sleep are tightly linked to short-cycle, frequent, and moderate CSF fluctuations. In contrast, slow waves during light sleep and arousals produce slow, infrequent, and steep CSF signal changes. Rapid eye movements and sawtooth waves during REM sleep are also linked to CSF signal changes. Furthermore, CSF signals are significantly faster in frequency during deep than light sleep. These brain oscillations during light and deep sleep recruit essentially different brain networks, with deep sleep involving memory and homeostatic circuits. Thus, human deep sleep has a unique way of facilitating CSF dynamics that are distinctive from arousal mechanisms.
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