肿瘤微环境
肝细胞癌
免疫系统
癌症研究
CD8型
抄写(语言学)
逃避(道德)
巨噬细胞极化
细胞毒性T细胞
转录因子
下调和上调
PD-L1
免疫疗法
肿瘤相关巨噬细胞
化学
磷酸化
细胞培养
巨噬细胞
基因
细胞生物学
癌
免疫学
癌变
发病机制
作者
Wenbo Jia,Jinyi Wang,Weiming Yang,Zhijie Ding,Litao Liang,Chao Xu,Yanzhi Feng,Qingpeng Lv,Zhu Deming,Wenhu Zhao,Xiangyu Ling,Yong Yan,Xiaoming Ai,Yongping Zhou,Lianbao Kong,Wenzhou Ding
标识
DOI:10.1136/jitc-2025-012314
摘要
Our research reveals that the RCOR2/LIF axis within the hypoxic microenvironment of HCC plays a significant role in immune evasion and identifies novel biomarkers associated with tumor resistance to anti-PD-1 therapy. This study provides potential therapeutic targets for HCC.
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