A Novel Electrochemical Sensor Based on Cerium Oxide/Carbon Black Composite for Sensitive Detection of Dopamine

Abstract As a neurotransmitter, dopamine (DA) plays a pivotal role in regulating human physiological functions, therefore it is of great significance to realize reliable and accurate detection of DA. In this study, cerium oxide/carbon black (CeO2/CB) composite was prepared via stirring-assisted thermal synthesis, then glassy carbon electrode (GCE) was modified with CeO2/CB by drop-casting to fabricate CeO2/CB/GCE. Cyclic voltammetry demonstrated outstanding electrocatalytic activity of CeO2/CB/GCE for DA oxidation. Amperometric tests revealed that CeO2/CB/GCE exhibited a linear range of 0.1-500 µM, sensitivity of 39.57 µA mM-1, and detection limit of 43 nM for DA detection. Furthermore, CeO2/CB/GCE exhibited superior anti-interference capability, excellent stability, and high fabrication reproducibility. In addition, the reliability of CeO2/CB/GCE was validated through DA detection in DA hydrochloride injection samples.