Similarity of Biological Information Captured by [ 68 ]Ga-PSMA-11 PET and ASL Perfusion MRI in Glioblastoma

Our results highlight the similarity of biologic information captured by PSMA PET and ASL perfusion imaging in GBM. The tracer uptake observed in PSMA PET can also reliably reflect the spatial heterogeneity of the microvascular distribution of GBM. These findings provide compelling support for PSMA-targeted radiation therapy as an anti-angiogenic therapeutic strategy for patients with GBM, while also advancing our understanding of the mechanisms underlying PSMA tracer uptake.