RNA干扰
生物
核糖核酸
抄写(语言学)
细胞生物学
遗传学
基因
语言学
哲学
作者
Xuan Zhang,Duan Wang,Pingzhi Zhao,Yanwei Sun,Rong-Xiang Fang,Jian Ye
标识
DOI:10.1016/j.xplc.2023.100644
摘要
The molecular mechanism underlying phototherapy and light treatment, which utilize various wavelength spectrums of light, including near infrared (NIR), to cure human and plant diseases, is obscure. Here we identified NIR light confers antiviral immunity by positively regulating PHYTOCHROME-INTERACTING FACTOR 4 (PIF4)-activated RNA interference (RNAi) in plants. PIF4, a central transcription factor involved in light signaling, highly accumulates under NIR light in plants. PIF4 directly induces the transcription of two essential components of RNAi, RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) and ARGONAUTE 1 (AGO1), which play important roles in the resistance against both DNA and RNA viruses. Moreover, the pathogenic determinant βC1 protein, evolutionarily conserved and encoded by betasatellites, interacts with PIF4 and inhibits its positive regulation of RNAi by disrupting PIF4 dimerization. These findings shed light on the molecular mechanism of PIF4-mediated plant defense and provide a new perspective for the exploration of NIR treatment for antivirals.
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