AIEgen-based smart system for fungal-infected wound monitoring and on-demand photodynamic therapy

Smart portable systems with integrated diagnosis and treatment play an important role in modern life. Real-time evaluation of wound infection and providing on-demand therapies with a smart wound-dressing system is a promising way to treat wound infection and alleviate the problem of antibiotic resistance. Herein, a smart portable system that equips fungi-sensitive aggregation-induced emission luminogens (AIEgens), a mini-double light channel on a cellphone, and intelligent software is presented to monitor fungal infection within seconds and give 1-min photodynamic therapy via low-power white light irradiation (5 mW cm−2) and antifungal activities over 96%, which realized 1-week wound healing. The smart system, integrated with remote communications and image analysis software, can realize wireless data transmission, infection degree analysis, and medical advice given by doctors through the internet. This smart system relieves the emergency of world antibiotic resistance and lays a foundation for developing smart wound dressing and potential applications in preclinical research and diagnostics.