Effects of mismatch negative elicited by auditory deviant of horizontal locations in virtual space

The encoding of auditory spatial through neural circuits in auditory cortexes is ongoing research. The mismatch negativity (MMN) is a sensitive indicator of pre-attention auditory change detection, which has been to explore the potential mechanism of the auditory spatial information cortex. This paper studies the MMN response affected by the horizontal location deviance in virtual space using a passive oddball paradigm. The results showed that the MMN amplitude increased and latency decreased with the increase of spatial deviance at 30~90°, and the MMN amplitude and latency decreased with the increase of spatial deviance at 120~180°. But MMN amplitude and latency did not show obvious regularity at 180~330°. The topography showed that the right spatial deviance processed by the auditory system had the contralateral hemisphere dominance, and the left spatial deviance processed by the auditory system may be the combination of the right and contralateral hemisphere dominance. This study not only helps to further understand the pre-conscious processing mechanism of auditory spatial but also provides an objective reference for doctors to evaluate spatial hearing ability.