光热治疗
活性氧
光动力疗法
肿瘤微环境
体内
细胞凋亡
化学
联合疗法
体外
癌症
癌症治疗
癌细胞
癌症治疗
癌症研究
生物物理学
纳米技术
肿瘤细胞
药理学
材料科学
医学
生物化学
生物
内科学
生物技术
有机化学
作者
Yuting Peng,Lianghao Cheng,Chunyi Luo,Fuquan Xiong,Zhongbiao Wu,Lin Zhang,Peng Zhan,Lishu Shao,Wenjie Luo
标识
DOI:10.1016/j.cej.2023.142370
摘要
Tumor microenvironment response and spatio-temporal targeting are promising strategies to combination therapy. By regulating the tumor microenvironment and realizing the precise targeted therapy, the antitumor efficacy can be significantly improved while maintaining low side effects. Therefore, in this study, a reactive oxygen species (ROS)-responsive nanosystem (MND-IR@RESV) was constructed. The MND-IR@RESV nanosystem could be accurately tracked and located due to its own fluorescence. Mitochondria-targeted nanosystem promoted the release of ROS and contributed to the apoptosis of cancer cells. The MND-IR@RESV responded significantly to ROS, which promoted the deep release of drugs. Furthermore, the system also possessed high photothermal conversion efficiency and photothermal stability, which could achieve spatio-temporal targeting of drugs and ensure the efficient tumor eradication ability of Chemo/Photothermal/Photodynamic (CT-PTT-PDT) combination therapy. Both in vitro and in vivo tests demonstrated the significant antitumor effect of the MND-IR@RESV. Importantly, the nanosystem had the advantages of low toxicity and few side effects that conventional CT lacks, indicating that the MND-IR@RESV holds great promise in future cancer treatment.
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