纳米医学
纳米载体
纳米技术
抗菌活性
抗生素
耐受性
药物输送
纳米颗粒
材料科学
医学
药理学
微生物学
生物
细菌
不利影响
遗传学
作者
Zhidong Zhou,Mingxuan Kai,Shuyan Wang,Dan Wang,Yifei Peng,Yiyan Yu,Weiwei Gao,Liangfang Zhang
摘要
Abstract The rise of antibiotic resistance has caused the prevention and treatment of bacterial infections to be less effective. Therefore, researchers turn to nanomedicine for novel and effective antibacterial therapeutics. The effort resulted in the first‐generation antibacterial nanoparticles featuring the ability to improve drug tolerability, circulation half‐life, and efficacy. Toward developing the next‐generation antibacterial nanoparticles, researchers have integrated design elements that emphasize physical, broad‐spectrum, biomimetic, and antivirulence mechanisms. This review highlights four emerging antibacterial nanoparticle designs: inorganic antibacterial nanoparticles, responsive antibacterial nanocarriers, virulence nanoscavengers, and antivirulence nanovaccines. Examples in each design category are selected and reviewed, and their structure–function relationships are discussed. These emerging designs open the door to nontraditional antibacterial nanomedicines that rely on mechano‐bactericidal, function‐driven, nature‐inspired, or virulence‐targeting mechanisms to overcome antibiotic resistance for more effective antibacterial therapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
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