共晶
药品
和厚朴酚
无定形固体
升华(心理学)
结晶度
溶解度
研磨
化学
材料科学
有机化学
药理学
氢键
医学
结晶学
色谱法
分子
心理学
复合材料
心理治疗师
作者
Yanli Zhang,Hong-Liang Lü,Zongxin Chen,Jialei Meng,Yunfeng Li,Qi Li,Suiliang Zhang,Xin Chen,Ming Liu
出处
期刊:Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials
[Wiley]
日期:2023-11-15
卷期号:79 (6)
标识
DOI:10.1107/s2052520623008648
摘要
A drug–drug cocrystal created with two antithrombotic-active ingredients from herbs, honokiol ( HON ) and ligustrazine ( TMP , 1:1), was synthesized and characterized. The structure of HON – TMP (1:1) was determined by single-crystal X-ray diffraction. Then co-amorphous HON – TMP was prepared by honey-assisted grinding, which was inspired by a grinding process for a Chinese patent medicine-Shijunzi honey pill. This co-amorphous drug–drug cocrystal (20% honey) exhibits improved solubility over HON and a significantly reduced sublimation tendency than TMP .
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