不确定意义的单克隆抗体病
多发性骨髓瘤
淀粉样变性
单克隆
单克隆抗体病
游戏病
医学
单克隆抗体
华登氏巨球蛋白血症
病理
副蛋白血症
免疫学
抗体
淋巴瘤
作者
Yuh Ping Chong,Say Min Lim,Tze Ping Loh,Peter Mollee,Nilika Wijeratne,Kay Weng Choy
标识
DOI:10.1136/jcp-2023-208774
摘要
Monoclonal gammopathy is a spectrum of disorders characterised by clonal proliferation of plasma cells or lymphocytes, which produce abnormal immunoglobulin or its components (monoclonal proteins). Monoclonal gammopathies are often categorised as low-tumour-burden diseases (eg, amyloid light chain (AL) amyloidosis), premalignant disorders (such as monoclonal gammopathy of undetermined significance and smouldering multiple myeloma), and malignancies (eg, multiple myeloma and Waldenström's macroglobulinaemia). Such diversity of concentration and structure makes monoclonal protein a challenging clonal marker. This article provides an overview on initial laboratory testing of monoclonal gammopathy to guide clinicians and laboratory professionals in the selection and interpretation of appropriate investigations.
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