Noncontact longitudinal shear wave imaging for the evaluation of heterogeneous porcine brain biomechanical properties using optical coherence elastography

弹性成像 成像体模 光学相干层析成像 生物医学工程 材料科学 传感器 超声波传感器 超声波 横波 声学 光学 剪切(地质) 医学 物理 复合材料
作者
Yirui Zhu,Jiulin Shi,Tomás Gómez Álvarez‐Arenas,Chenxi Li,Haohao Wang,Dong Zhang,Xingdao He,X. S. Wu
出处
期刊:Biomedical Optics Express [Optica Publishing Group]
卷期号:14 (10): 5113-5113 被引量:5
标识
DOI:10.1364/boe.497801
摘要

High-resolution quantification of heterogeneous brain biomechanical properties has long been an important topic. Longitudinal shear waves (LSWs) can be used to assess the longitudinal Young's modulus, but contact excitation methods have been used in most previous studies. We propose an air-coupled ultrasound transducer-based optical coherence elastography (AcUT-OCE) technique for noncontact excitation and detection of LSWs in samples and assessment of the nonuniformity of the brain's biomechanical properties. The air-coupled ultrasonic transducer (AcUT) for noncontact excitation of LSWs in the sample has a center frequency of 250 kHz. Phase-resolved Doppler optical coherence tomography (OCT) was used to image and reconstruct the propagation behavior of LSWs and surface ultrasound waves at high resolution. An agar phantom model was used to verify the feasibility of the experimental protocol, and experiments with ex vivo porcine brain samples were used to assess the nonuniformity of the brain biomechanical properties. LSWs with velocities of 0.83 ± 0.11 m/s were successfully excited in the agar phantom model. The perivascular elastography results in the prefrontal cortex (PFC) of the ex vivo porcine brains showed that the Young's modulus was significantly higher in the longitudinal and transverse directions on the left side of the cerebral vessels than on the right side and that the Young's modulus of the PFC decreased with increasing depth. The AcUT-OCE technique, as a new scheme for LSW applications in in vivo elastography, can be used for noncontact excitation of LSWs in brain tissue and high-resolution detection of heterogeneous brain biomechanical properties.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
XLL小绿绿发布了新的文献求助10
刚刚
江幻天发布了新的文献求助10
3秒前
重要涔雨完成签到,获得积分10
5秒前
静静发布了新的文献求助10
5秒前
JinlongFan完成签到 ,获得积分10
5秒前
acc完成签到,获得积分10
7秒前
脑洞疼应助阿九采纳,获得10
7秒前
科目三应助韩凡采纳,获得10
9秒前
10秒前
10秒前
13秒前
14秒前
喵呜完成签到,获得积分10
14秒前
15秒前
15秒前
15秒前
16秒前
深情安青应助lzz采纳,获得10
17秒前
18秒前
18秒前
18秒前
小四喜发布了新的文献求助10
20秒前
bc发布了新的文献求助10
20秒前
喵呜发布了新的文献求助10
20秒前
Orange应助yinyue采纳,获得10
20秒前
wyl发布了新的文献求助10
21秒前
鲜于元龙发布了新的文献求助10
22秒前
XIAOLIANG发布了新的文献求助10
22秒前
22秒前
7777777发布了新的文献求助10
23秒前
Orange应助弓纪世采纳,获得10
23秒前
科研助手6应助加贝采纳,获得10
23秒前
26秒前
糊涂的MJ完成签到,获得积分10
26秒前
缓慢的翅膀完成签到,获得积分10
26秒前
李爱国应助跳跃虔采纳,获得10
26秒前
27秒前
27秒前
wz发布了新的文献求助20
27秒前
bc完成签到,获得积分10
29秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3800438
求助须知:如何正确求助?哪些是违规求助? 3345676
关于积分的说明 10326678
捐赠科研通 3062182
什么是DOI,文献DOI怎么找? 1680882
邀请新用户注册赠送积分活动 807268
科研通“疑难数据库(出版商)”最低求助积分说明 763572