Polygonatum sibiricum polysaccharide inhibits the proliferation of endometrial cancer cells by promoting cell death

Endometrial cancer (EC) is a type of malignant tumor with increasing global incidence and mortality rates, especially in regions with high rates of obesity. Polygonatum sibiricum polysaccharide (PSP) has shown promise in addressing deficiencies associated with EC. While PSP has demonstrated anti-cancer properties across various cancer types, its efficacy in EC remains underexplored. This study investigates the inhibitory effects of PSP on EC cell proliferation and autophagy. Our data demonstrate that PSP effectively inhibits the growth of EC cells and induces apoptosis. Furthermore, PSP triggers autophagy in EC cells. Mechanistically, PSP suppresses the Toll-like receptors (TLR4)/Signal Transducer and Activator of Transcription 3 (STAT3) pathway, thereby inhibiting EC progression. In conclusion, our findings highlight the significant therapeutic potential of PSP in EC treatment by inhibiting cell growth, inducing apoptosis, and triggering autophagy via the TLR4/STAT3 pathway.