坏死性下垂
上睑下垂
程序性细胞死亡
生物
半胱氨酸蛋白酶
信号转导
细胞凋亡
细胞生物学
计算生物学
神经科学
遗传学
作者
Ke-Qian Chen,Shuzhi Wang,Haibo Lei,Xiang Liu
标识
DOI:10.3389/fcell.2024.1428250
摘要
Oxeiptosis is a novel cell death pathway that was introduced in 2018. As a form of regulated cell death, it operates independently of caspases and is induced by ROS. Distinguished from other cell death pathways such as apoptosis, necroptosis, pyroptosis, and ferroptosis, oxeiptosis features unique damage causes pivotal genes, and signaling pathways (KEAP1/PGAM5/AIFM1). Emerging studies indicate that oxeiptosis plays a significant role in the progression of various diseases and its regulation could serve as a promising therapeutic target. However, the precise molecular mechanisms underlying oxeiptosis remain to be fully elucidated. In this mini-review, we systematically summarize the latest developments in oxeiptosis-related diseases while detailing the molecular mechanisms and regulatory networks of oxeiptosis. These insights offer a foundation for a deeper understanding of oxeiptosis.
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