层状结构
液晶
小泡
胶束
化学
相(物质)
层状相
结晶学
偏振光显微镜
相变
溶致性
中子散射
相图
两亲性
膜
散射
材料科学
液晶
有机化学
热力学
水溶液
光学
生物化学
物理
光电子学
共聚物
聚合物
作者
Thad A. Harroun,Martin Koslowsky,Mu‐Ping Nieh,Charles‐François de Lannoy,V. A. Raghunathan,John Katsaras
出处
期刊:Langmuir
[American Chemical Society]
日期:2005-05-12
卷期号:21 (12): 5356-5361
被引量:105
摘要
Mixtures of long- and short-chain phospholipids, specifically 14:0 and 6:0 phosphatidylcholines (DMPC and DHPC), have been used successfully in NMR studies as magnetically alignable substrates for membrane-associated proteins. However, recent publications have shown that the phase behavior of these mixtures is much more complex than originally thought. Using polarized light microscopy and small-angle neutron scattering, phase diagrams of DMPC/DHPC mixtures at molar ratios of 2, 3.2, and 5 have been determined. Generally, at temperatures below the main-chain melting transition of DMPC (T(M) = 23 degrees C), an isotropic phase of disk-like micelles is found. At high temperatures (T > 50 degrees C), a lamellar phase consisting of either multilamellar vesicles (MLV) or extended lamellae is formed, which at low lipid concentrations (e.g., MLV) coexists with an excess of water. At intermediate temperatures and lipid concentrations, a chiral nematic phase made up of worm-like micelles was observed.
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